Our publications

Weber, F#; Rahnfeld, L#; Luciani, P* Analytical profiling and stability evaluation of liposomal drug delivery systems: a rapid UHPLC-CAD-based approach for phospholipids in research and quality control. Talanta 2020, 121320, doi:10.1016/j.talanta.2020.121320
(#contributed equally, *PL corresponding author)

Rahnfeld L, Luciani P*. Injectable Lipid-Based Depot Formulations: Where Do We Stand? Pharmaceutics 2020, 12, 567. (*PL corresponding author)

Zivko C, Fuhrmann G*, Luciani P*. Liver-derived extracellular vesicles: A cell by cell overview to isolation and characterization practices. Biochim Biophys Acta Gen Subj. (2020) doi: 10.1016/j.bbagen.2020.129559 (*PL co-corresponding author)

Valentino G, Zivko C, Weber F, Brülisauer L, Luciani P*. Synergy of Phospholipid—Drug Formulations Significantly Deactivates Profibrogenic Human Hepatic Stellate Cells. Pharmaceutics 2019, 11(12), 676 (*PL corresponding author)

Sutter D, Dzhonova DV, Prost JC, Bovet C, Banz Y, Rahnfeld L, Leroux JC, Rieben R, Vögelin E*, Plock JA*, Luciani P*, Taddeo A*, Schnider JT. Delivery of rapamycin using in situ forming implants promotes immunoregulation and vascularized composite allograft survival. Sci Rep (2019) 9:9269 (*PL co-corresponding author)

Papachristodoulou A, Signorell RD, Werner B, Brambilla D, Luciani P, Cavusoglu M, Grandjean J, Silginer M, Rudin M, Martin E, Weller M, Roth P, Leroux JC. Chemotherapy sensitization of glioblastoma by focused ultrasound-mediated delivery of therapeutic liposomes. J Control Release (2019) 295:130-139

Signorell R.D, Luciani P, Brambilla D, Leroux JC. Pharmacokinetics of lipid-drug conjugates loaded into liposomes. Eur J Pharm Biopharm (2018) 128:188-199

Rahnfeld L, Thamm J, Steiniger F, van Hoogevest P, Luciani P*. Study on the in situ aggregationof liposomes with negatively charged phospholipids for use as injectable depot formulation.Colloids Surf B Biointerfaces (2018) 168:10-17 (*PL corresponding author)

Ristori S, Grillo I, Lusa S, Thamm J, Valentino G, Campani V, Caraglia M, Steiniger F, Luciani P, De Rosa G. Structural Characterization of self-assembling hybrid nanoparticles for bisphosphonate delivery in tumors. Mol Pharm (2018) 15:1258-1265

Signorell RD, Papachristodoulou A, Xiao J, Arpagaus B, Casalini T, Grandjean J, Thamm J, Steiniger F, Luciani P, Brambilla D, Werner B, Martin E, Weller M, Roth P, Leroux JC.Preparation of PEGylated liposomes incorporating lipophilic lomeguatrib derivatives for the sensitization of chemo-resistant gliomas. Int J Pharm (2018) 536:388-396

Pratsinis A, Zürcher S, Forster V, Fischer EJ, Luciani P, Leroux JC. Ethanol metabolism by liposome-supported enzymatic peritoneal dialysis. Biomaterials(2017) 145:128-137.

Luciani P, Estella-Hermoso de Mendoza A, Casalini T, Lang S, Atrott K, Spalinger MR, Frey-Wagner I, Schumacher J, Leroux JC, Rogler G. Gastroresistant oral peptide for fluorescence imaging of colonic inflammation. Control. Release(2017) 226:118-126.

Andina D,Leroux JC*, Luciani P*. Ratiometric fluorescent probes to detect reactive oxygen and nitrogen species. Eur. J.(2017), 23:13549-13573. (*PL co-corresponding author)

Roveri M, Pfohl A, Jaaks P, Alijaj N, Leroux JC, Luciani P*, Bernasconi M*. Prolonged circulation and increased tumor accumulation of liposomal vincristine in a mouse model of rhabdomyosarcoma. Nanomedicine (Lond.)(2017), 12:1135-1151.(*PL co-corresponding author)

Andina D, Brambilla D, Frei J, Munzinger N, Zivko C, Leroux JC*,Luciani P*. Development of a Modular Ratiometric Fluorescent Probe for the Detection of Extracellular Superoxide. Eur. J.(2017), 23:4765-4769. Selected as “Hot Topic” by Wiley-VCH. Highlightedin www.chemistryviews.org.(*PL co-corresponding author)

Roveri M, Bernasconi M, Leroux JC, Luciani P*. Peptides for tumor-specific drug targeting: state of the art and beyond. Mater. Chem. B, (2017) 5:4348-4364.Themed Issue“Emerging Investigators 2017”.(*PL corresponding author)

Chong C, Scholkmann F, Bachmann SB, Luciani P, Leroux JC, Detmar M, Proulx ST. In vivovisualization and quantification of collecting lymphatic vessel contractility using near-infrared imaging. Rep.(2016) 6, 22930.

Karaman S, Buschle D, Luciani P, Leroux JC, Detmar M, Proulx ST. Decline of lymphatic vessel density and function in murine skin during aging. Angiogenesis(2015) 18:449-498.

Zolla V,Nizamutdinova IT, Scharf B, Clement CC, Maejima D, Akl T, Nagai T, Luciani P, Leroux JC, Halin C,  Stukes S, Tiwari S , Casadevall A, Jacobs WR, Entemberg D, Zawieja D, Condeelis J, Fooksman DR, Gashev AA, Santambrogio L. Aging-related anatomical and biochemical changes in lymphatic collectors impair lymph drainage, fluid homeostasis and pathogen transport. Aging Cell.(2015) 14:582-94.

Brambilla D, Luciani P, Leroux J.C. Breakthrough Discoveries in Drug Delivery Technologies: The Next 30 Years. Invited review for the special issues for the 30thyears of Control. Release(2014) 190:9-14.

Blum KS, Karaman S, Proulx ST, Ochsenbein AM, Luciani P, Leroux JC, Wolfrum C, Detmar M. Chronic high-fat diet impairs collecting lymphatic vessel function in mice. PLoS One(2014), 9: e94713.

Proulx ST, Luciani P, Dieterich L, Karaman S, Leroux JC, Detmar M. Expansion of the lymphatic vasculature in cancer and inflammation: New opportunities for in vivo imaging and drug delivery. Control. Release(2013) 172:550-557.

Fuhrmann G, Grotzky A, Lukic R, Matoori S, Luciani P, Yu H, Zhang B,Walde P, Schlüter AD, Gauthier MA, Leroux JC.Sustained gastrointestinal activity of dendronized polymer–enzyme conjugates.Nature Chem. (2013) 7: 582-589.Highlighted in:Nat Chem2013; 5:557-558, SciBX6 (27) 2013, DOI:10.1038/scibx.2013.707 and Chimia2014; 68:85.

Blum KS, Proulx ST, Luciani P, Leroux JC, Detmar M. Dynamics of lymphatic generation and flow patterns after lymph node dissection. Breast Cancer Res. Treat. (2013), 139:81-86.

Proulx ST, Luciani P, Christiansen A, Karaman S, Blum K, Rinderknecht M, Leroux JC, Detmar D. Use of a PEG-conjugated bright near-infrared dye for functional imaging of rerouting of lymphatic tumor drainage after sentinel lymph node metastasis. Biomaterials (2013), 34:5128-5137.

(*) Proulx ST, Luciani P, Alitalo A, Mumprecht V, Huggenberger R, Leroux JC, Detmar D. Non-invasive dynamic near-infrared imaging and quantification of vascular leakage in vivo. Angiogenesis(2013) 16:525-540. (*) Shared first authorship. Featured on cover.

Duong T, Proulx ST, Luciani P, Leroux JC, Detmar D, Francois M, Koopman P. Genetic ablation of SOX18 function suppresses neo-lymphangiogenesis and tumor metastasis in a mouse model of melanoma. Cancer Res.(2012)72:3105-14.

Ridi F,Fratini E, Luciani P, Winnefeld F, Baglioni P. Tricalcium silicate hydration reaction in the presence of comb-shaped superplasticizers: Boundary Nucleation and Growth Model applied to polymer-modified pastes. Phys. Chem. C(2012) 116:10887–10895.

Forster V, Luciani P, Leroux JC. Treatment of calcium channel blocker-induced cardiovascular toxicity with drug scavenging liposomes.Biomaterials(2012) 33:3578-3585.

Ridi F,Fratini E, Luciani P, Winnefeld F, Baglioni P. Hydration of tricalcium silicate: Monitoring by calorimetric methods and modeling of hydration kinetics. Colloid Interface Sci.(2011) 364:118-124.

Luciani P, Fevre M, Leroux JC. Development and physico-chemical characterization of a liposomal formulation of istaroxime. J. Pharm. Biopharm. (2011) 79:285-293.

Proulx ST(*), Luciani P(*),Derzsi S, Rinderknecht M, Mumprecht V, Leroux JC, Detmar M. Quantitative imaging of lymphatic function with liposomal indocyanine green. Cancer Res. (2010) 70:7053–62. Highlighted inBreaking Advances from Recent Cancer Literature:Cancer Res.(2010) 70:7345.(*)Shared first authorship

Luciani P,Berti D, Fortini M, Baglioni P, Gherardini C, Bartolini A, Pacini A, Manetti D, Gualtieri F, Di Cesare Mannelli L. Receptor-independent modulation of reconstituted Gαi protein mediated by liposomes. BioSys.(2009) 5:356-367. Featured on cover.

Ridi F, Luciani P,Fratini E, Baglioni P. Water Confined in Cement Pastes as a Probe of Cement Microstructure Evolution. Phys. Chem. B (2009) 113:3080-3087.

Bombelli C, Giansanti L, Luciani P,Mancini G. Gemini surfactant based carriers in drug and gene delivery. Med. Chem.(2009) 16:171-183.

Molinari A, Bombelli C, Mannino S, Stringaro A, Toccacieli L, Calcabrini A, Colone M, Bozzuto G, Mangiola A, Maira G, Luciani P,Mancini G, Arancia G. A new transfection strategy in the photodynamic therapy of malignant gliomas. Cytometry A (2008) 73A: 66.

(**)Bombelli C, Faggioli F, Giansanti L, Luciani P,Sacco MG. PEGylated lipoplexes: preparation protocols affecting DNA condensation and cell transfection efficiency. Med. Chem.(2007) 50:6274-6278. (**) Authors listed in alphabetical order, but contribution as first author

Caracciolo G, Pozzi D, Caminiti R, Mancini G, Luciani P,Amenitsch H. Observation of a Rectangular DNA Superlattices in the Liquid Crystalline Phase of Cationic Lipid/DNA Complexes. Am. Chem. Soc.(2007) 129:10092-10093.

Luciani P,Bombelli C, Colone M, Giansanti L, Ryhänen SJ, Säily VMJ, Mancini G, Kinnunen PKJ. Influence of the Spacer of Cationic Gemini Amphiphiles on the Hydration of Lipoplexes. Biomacromolecules(2007) 8:1999-2003.

Molinari A, Bombelli C, Mannino S, Stringaro A, Toccacieli L, Calcabrini A, Colone M, Mangiola A, Maira G, Luciani P,Mancini G, Arancia G. m-THPC-mediated photodynamic therapy of malignant gliomas: Assessment of a new transfection strategy. J. Cancer (2007), 121:1149-1155.

Ryhänen SJ, Säily VMJ, Parry MJ, Luciani P,Mancini G, Alakoskela JMI, Kinnunen PKJ. A Counterion Controlled Transition of a Cationic Gemini from Submicroscopic to Giant Vesicles. Am. Chem. Soc.(2006), 128:8659-8663.

Säily VMJ, Ryhänen SJ, Lankinen H, Luciani P,Mancini G, Parry MJ, Kinnunen PKJ. Impact of Reductive Cleavage of an Intramolecular Disulfide Bond Containing Cationic Gemini Surfactant in Monolayers and Bilayers. Langmuir (2006), 22:956-962.

(**)Bombelli C, Borocci S, Diociaiuti M, Faggioli F, Galantini L, Luciani P,Mancini G, Sacco MG. Role of the spacer of cationic gemini amphiphiles in the condensation of DNA.Langmuir(2005) 21:10271-10274. (**) Authors listed in alphabetical order, but contribution as first author

(**)Bombelli C, Faggioli F, Luciani P,Mancini G, Sacco MG. Efficient Transfection of DNA by Liposomes Formulated with Cationic Gemini Amphiphiles. Med. Chem.(2005) 48:5378-5382. (**) Authors listed in alphabetical order, but contribution as first author

Bombelli C, Caracciolo G, Di Profio P, Diociaiuti M, Luciani P,Mancini G, Mazzuca C, Marra M, Molinari A, Monti D, Toccacieli L, Venanzi M. Inclusion of a Photosensitizer in Liposomes Formed by DMPC/Gemini Surfactant: Correlation between Physicochemical and Biological Features of the Complexes. Med. Chem.(2005) 48:4882-4891.

Caracciolo G, Mancini G, Bombelli C,Luciani P,Caminiti R. The Structure of Gemini Surfactant Self-Assemblies Investigated by Energy Dispersive X-ray Diffraction. J. Phys. Chem. B (2003) 107:12268-12274

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