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66. Dzhumashev D, Anton-Joseph S, Morel VJ, Timpanaro A, Bordon G, Piccand C, Aleandri S, Luciani P, Rössler J, Bernasconi M. Rapid liposomal formulation for nucleolin targeting to rhabdomyosarcoma cells. Eur. J. Pharm. Biopharm. (2023) In press.
65. Eugster R, Ganguin AA, Seidi A, Aleandri S, Luciani P*. 3D printing injectable microbeads using a composite liposomal ink for local treatment of peritoneal diseases. Drug Deliv. Transl. Res. (2023) doi:10.1007/s13346-023-01472-y. (*PL corresponding author)
64. Zimmermann CM, Deßloch L, Jürgens DC, Luciani P, Merkel OM. Evaluation of the effects of storage conditions on spray-dried siRNA-LNPs before and after subsequent drying. Eur. J. Pharm. Biopharm. (2023) 193:218-226
63. Bordon G, Berenbaum F, Distler O, Luciani P*. Harnessing the multifunctionality of lipid-based drug delivery systems for the local treatment of osteoarthritis. Biomed. Pharmacother. (2023) 168:115819 (*PL corresponding author)
62. Skorup I#, Valentino G#, Aleandri S, Gelli R, Ganguin AA, Felli E, Selicean SE, Marxer RA, Teworte S, Lucic A, Gracia-Sancho J, Berzigotti A, Ridi F, Luciani P*. Polyenylphosphatidylcholine as bioactive excipient in tablets for the treatment of liver fibrosis. Int. J. Pharm. (2023) 646:123473 (# contributed equally, *PL corresponding author)
61. Ganguin AA, Skorup I, Streb S, Othman A, Luciani P*. Formation and investigation of cell-derived nanovesicles as potential therapeutics against chronic liver disease. Adv. Healthc. Mat. (2023) 2300811 (*PL corresponding author)
60. Bordon G, Ramakrishna SN, Edalat SG, Eugster R, Arcifa A, Vermathen M, Aleandri S, Frank Bertoncelj M, Furrer J, Vermathen P, Isa L, Crockett R, Distler O, Luciani P*. Liposomal aggregates sustain the release of rapamycin and protect cartilages from friction. J. Colloid Interface Sci. (2023) 650:1659-1670 (*PL corresponding author)
59. Teworte S, Aleandri S, Weber J.R, Carone M, Luciani P*. Mucoadhesive 3D printed vaginal ovules to treat endometriosis and fibrotic uterine disease. Eur. J. Pharm. Sci. (2023) 188:106501 (*PL corresponding author)
58. Carone M#, Spalinger MR#, Gaultney RA#, Mezzenga R, Hlakackova K, Mookhoek A, Krebs P*, Rogler G*, Luciani P*, Aleandri S*. Temperature-triggered in situ forming gel for local treatment of ulcerative colitis. Nature Commun. (2023) 14:3489 (#contributed equally, *PK, *GR, *PL, *SA co-corresponding authors). Featured in the “Editors’ Highlights, Biotechnology and Methods” of Nature Communications.
57. Spera I, Cousin N, Ries M, Kedracka A, Castillo A, Aleandri S, Vladymyrov M, Mapunda JA, Engelhardt B, Luciani P, Detmar M, Proulx S. Open pathways for cerebrospinal fluid outflow at the cribriform plate along the olfactory nerves. eBioMedicine (2023) 91:104558.
56. Zivko C, Witt F, Koeberle A, Fuhrmann G*, Luciani P*. Formulating elafibranor and obeticholic acid with phospholipids decreases drug-induced association of SPARC to extracellular vesicles from LX-2 hepatic stellate cells. Eur. J. Pharm. Biopharm. (2023) 182:32-40 (*PL co-corresponding author)
55. Teworte S, Luciani P*. Endometriosis, the client disease: molecular targets, active principle, and drug delivery systems. Helv. Chim. Acta (2023) 106:e202200132 (*PL corresponding author)
54. Aleandri S#, Rahnfeld L#, Chatzikleanthous D, Bergadano A, Bühr C, Detotto C, Fuochi S, Weber-Wilk K, Schürch S, van Hoogevest P, Luciani P*. Development and in vivo validation of phospholipid-based depots for the sustained release of buivacaine. Eur. J. Pharm. Biopharm. (2022) 181:300-309 (#contributed equally, *PL corresponding author)
53. Zivko C, Fuhrmann K, Fuhrmann G*, Luciani P*. Tracking matricellular protein SPARC in extracellular vesicles as a non-destructive method to evaluate lipid-based antifibrotic treatments. Commun. Biol. (2022) 5:1155 (*PL co-corresponding author)
52. Zimmermann CM, Baldassi D, Chan K, Adams NBP, Neumann A, Porras-Gonzalez DL, Wei X, Kneidinger N, Stoleriu MG, Burgstaller G, Witzigmann D, Luciani P, Merkel OM. Spray drying siRNA-lipid nanoparticles for dry powder pulmonary delivery. J Control. Release (2022) 351:137-150.
51. Elzenaty O, Luciani P, Aleandri S*. A lipidic mesophase with tunable release properties for the local delivery of macromolecules: the apoferritin nanocage, a case study. J. Mater. Chem. B (2022) 10:3876-3885 (*SA corresponding author)
50. Weber F, Casalini T, Valentino G, Brülisauer L, Andreas N, Koeberle A, Kamradt T, Casalini A, Luciani P*. Targeting transdifferentiated hepatic stellate cells and monitoring the hepatic fibrogenic process by means of IGF2R-specific peptides designed in silico. J Mater. Chem. B (2021) 9:2092-2106 (PL* corresponding author).
49. Weber F, Ivan D, Proulx ST, Locatelli G, Aleandri S*, Luciani P*. Beyond trial-and-error: a systematic development of liposomes targeting primary macrophages. Adv. NanoBiomed Res. (2021) 1:2000098 (*SA and *PL co-corresponding author)
48. Cardinell K, Gupta N, Koivisto BD, Kumaradas JC, Zhou X, Irving H, Luciani P, Yücel YH. A novel photoacoustic-fluorescent contrast agent for quantitative imaging of lymphatic drainage. Photoacoustics (2021) 21:100239.
47. Zivko C, Fuhrmann G*, Luciani P*. Liver-derived extracellular vesicles: A cell by cell overview to isolation and characterization practices. Biochim. Biophys. Acta Gen. Subj. (2021) 1865:129559 (*PL co-corresponding author)
46. Alijaj N, Moutel S, Gouveia ZL, Gary M, Roveri M, Dzhumashev D, Weber F, Meier G, Luciani P, Schäfer BW, Rössler J, Perez F, Bernasconi M. Novel FGFR4-targeting single domain antibodies for multiple targeted therapies against rhabdomyosarcoma. Cancers (2020) 12:3313.
45. Weber F#, Rahnfeld L#, Luciani P*. Analytical profiling and stability evaluation of liposomal drug delivery systems: a rapid UHPLC-CAD-based approach for phospholipids in research and quality control. Talanta (2020) 120:121320 (#contributed equally, *PL corresponding author)
44. Rahnfeld L, Luciani P*. Injectable Lipid-Based Depot Formulations: Where Do We Stand? Pharmaceutics (2020) 12, 567 (*PL corresponding author). Top downloaded paper June-Dec 2020 in Pharmaceutics.
43. Valentino G, Zivko C, Weber F, Brülisauer L, Luciani P*. Synergy of Phospholipid—Drug Formulations Significantly Deactivates Profibrogenic Human Hepatic Stellate Cells. Pharmaceutics (2019) 11:676 (*PL corresponding author)
42. Sutter D, Dzhonova DV, Prost JC, Bovet C, Banz Y, Rahnfeld L, Leroux JC, Rieben R, Vögelin E*, Plock JA*, Luciani P*, Taddeo A*, Schnider JT. Delivery of rapamycin using in situ forming implants promotes immunoregulation and vascularized composite allograft survival. Sci. Rep. (2019) 9:9269 (*PL co-corresponding author)
41. Papachristodoulou A, Signorell RD, Werner B, Brambilla D, Luciani P, Cavusoglu M, Grandjean J, Silginer M, Rudin M, Martin E, Weller M, Roth P, Leroux JC. Chemotherapy sensitization of glioblastoma by focused ultrasound-mediated delivery of therapeutic liposomes. J Control. Release (2019) 295:130-139
40. Signorell R.D, Luciani P, Brambilla D, Leroux JC. Pharmacokinetics of lipid-drug conjugates loaded into liposomes. Eur. J. Pharm. Biopharm. (2018) 128:188-199
39. Rahnfeld L, Thamm J, Steiniger F, van Hoogevest P, Luciani P*. Study on the in situ aggregationof liposomes with negatively charged phospholipids for use as injectable depot formulation.Colloids Surf. B Biointerfaces (2018) 168:10-17 (*PL corresponding author)
38. Ristori S, Grillo I, Lusa S, Thamm J, Valentino G, Campani V, Caraglia M, Steiniger F, Luciani P, De Rosa G. Structural Characterization of self-assembling hybrid nanoparticles for bisphosphonate delivery in tumors. Mol. Pharm. (2018) 15:1258-1265
37. Signorell RD, Papachristodoulou A, Xiao J, Arpagaus B, Casalini T, Grandjean J, Thamm J, Steiniger F, Luciani P, Brambilla D, Werner B, Martin E, Weller M, Roth P, Leroux JC.Preparation of PEGylated liposomes incorporating lipophilic lomeguatrib derivatives for the sensitization of chemo-resistant gliomas. Int. J. Pharm. (2018) 536:388-396
36. Pratsinis A, Zürcher S, Forster V, Fischer EJ, Luciani P, Leroux JC. Ethanol metabolism by liposome-supported enzymatic peritoneal dialysis. Biomaterials (2017) 145:128-137.
35. Luciani P, Estella-Hermoso de Mendoza A, Casalini T, Lang S, Atrott K, Spalinger MR, Frey-Wagner I, Schumacher J, Leroux JC, Rogler G. Gastroresistant oral peptide for fluorescence imaging of colonic inflammation. J. Control. Release (2017) 262:118-126.
34. Andina D, Leroux JC*, Luciani P*. Ratiometric fluorescent probes to detect reactive oxygen and nitrogen species. Chem. Eur. J.(2017) 23:13549-13573. (*PL co-corresponding author)
33. Roveri M, Pfohl A, Jaaks P, Alijaj N, Leroux JC, Luciani P*, Bernasconi M*. Prolonged circulation and increased tumor accumulation of liposomal vincristine in a mouse model of rhabdomyosarcoma. Nanomedicine (Lond.) (2017) 12:1135-1151.(*PL co-corresponding author)
32. Andina D, Brambilla D, Frei J, Munzinger N, Zivko C, Leroux JC*, Luciani P*. Development of a Modular Ratiometric Fluorescent Probe for the Detection of Extracellular Superoxide. Chem. Eur. J. (2017) 23:4765-4769. Selected as “Hot Topic” by Wiley-VCH. Highlighted in www.chemistryviews.org. (*PL co-corresponding author)
31. Roveri M, Bernasconi M, Leroux JC, Luciani P*. Peptides for tumor-specific drug targeting: state of the art and beyond. J. Mater. Chem. B, (2017) 5:4348-4364.Themed Issue “Emerging Investigators 2017”.(*PL corresponding author)
30. Chong C, Scholkmann F, Bachmann SB, Luciani P, Leroux JC, Detmar M, Proulx ST. In vivo visualization and quantification of collecting lymphatic vessel contractility using near-infrared imaging. Sci. Rep.(2016) 6:22930.
29. Karaman S, Buschle D, Luciani P, Leroux JC, Detmar M, Proulx ST. Decline of lymphatic vessel density and function in murine skin during aging. Angiogenesis (2015) 18:449-498
28. Zolla V,Nizamutdinova IT, Scharf B, Clement CC, Maejima D, Akl T, Nagai T, Luciani P, Leroux JC, Halin C, Stukes S, Tiwari S , Casadevall A, Jacobs WR, Entemberg D, Zawieja D, Condeelis J, Fooksman DR, Gashev AA, Santambrogio L. Aging-related anatomical and biochemical changes in lymphatic collectors impair lymph drainage, fluid homeostasis and pathogen transport. Aging Cell (2015) 14:582-94
27. Brambilla D, Luciani P, Leroux J.C. Breakthrough Discoveries in Drug Delivery Technologies: The Next 30 Years. Invited review for the special issues for the 30thyears of J. Control. Release (2014) 190:9-14
26. Blum KS, Karaman S, Proulx ST, Ochsenbein AM, Luciani P, Leroux JC, Wolfrum C, Detmar M. Chronic high-fat diet impairs collecting lymphatic vessel function in mice. PLoS One (2014) 9: e94713
25. Proulx ST, Luciani P, Dieterich L, Karaman S, Leroux JC, Detmar M. Expansion of the lymphatic vasculature in cancer and inflammation: New opportunities for in vivo imaging and drug delivery. J. Control. Release (2013) 172:550-557
24. Fuhrmann G, Grotzky A, Lukic R, Matoori S, Luciani P, Yu H, Zhang B,Walde P, Schlüter AD, Gauthier MA, Leroux JC. Sustained gastrointestinal activity of dendronized polymer–enzyme conjugates. Nature Chem. (2013) 7: 582-589. Highlighted in: Nat Chem2013; 5:557-558, SciBX6 (27) 2013 and Chimia 2014; 68:85
23. Blum KS, Proulx ST, Luciani P, Leroux JC, Detmar M. Dynamics of lymphatic generation and flow patterns after lymph node dissection. Breast Cancer Res. Treat. (2013), 139:81-86
22. Proulx ST, Luciani P, Christiansen A, Karaman S, Blum K, Rinderknecht M, Leroux JC, Detmar M. Use of a PEG-conjugated bright near-infrared dye for functional imaging of rerouting of lymphatic tumor drainage after sentinel lymph node metastasis. Biomaterials (2013), 34:5128-5137
21. (*) Proulx ST, Luciani P, Alitalo A, Mumprecht V, Huggenberger R, Leroux JC, Detmar M. Non-invasive dynamic near-infrared imaging and quantification of vascular leakage in vivo. Angiogenesis (2013) 16:525-540. (*) Shared first authorship. Featured on cover
20. Duong T, Proulx ST, Luciani P, Leroux JC, Detmar D, Francois M, Koopman P. Genetic ablation of SOX18 function suppresses neo-lymphangiogenesis and tumor metastasis in a mouse model of melanoma. Cancer Res. (2012) 72:3105-14
19. Ridi F, Fratini E, Luciani P, Winnefeld F, Baglioni P. Tricalcium silicate hydration reaction in the presence of comb-shaped superplasticizers: Boundary Nucleation and Growth Model applied to polymer-modified pastes. J. Phys. Chem. C (2012) 116:10887–10895
18. Forster V, Luciani P, Leroux JC. Treatment of calcium channel blocker-induced cardiovascular toxicity with drug scavenging liposomes. Biomaterials (2012) 33:3578-3585.
17. Ridi F, Fratini E, Luciani P, Winnefeld F, Baglioni P. Hydration of tricalcium silicate: Monitoring by calorimetric methods and modeling of hydration kinetics. J. Colloid Interface Sci. (2011) 364:118-124
16. Luciani P, Fevre M, Leroux JC. Development and physico-chemical characterization of a liposomal formulation of istaroxime. Eur. J. Pharm. Biopharm. (2011) 79:285-293
15. Proulx ST(*), Luciani P(*), Derzsi S, Rinderknecht M, Mumprecht V, Leroux JC, Detmar M. Quantitative imaging of lymphatic function with liposomal indocyanine green. Cancer Res. (2010) 70:7053–62. Highlighted in Breaking Advances from Recent Cancer Literature: Cancer Res.(2010) 70:7345.(*) Shared first authorship
14. Luciani P, Berti D, Fortini M, Baglioni P, Gherardini C, Bartolini A, Pacini A, Manetti D, Gualtieri F, Di Cesare Mannelli L. Receptor-independent modulation of reconstituted Gαi protein mediated by liposomes. Mol. BioSys.(2009) 5:356-367. Featured on cover
13. Ridi F, Luciani P, Fratini E, Baglioni P. Water Confined in Cement Pastes as a Probe of Cement Microstructure Evolution. J. Phys. Chem. B (2009) 113:3080-3087
12. Bombelli C, Giansanti L, Luciani P, Mancini G. Gemini surfactant based carriers in drug and gene delivery. Curr. Med. Chem. (2009) 16:171-183.
11. Molinari A, Bombelli C, Mannino S, Stringaro A, Toccacieli L, Calcabrini A, Colone M, Bozzuto G, Mangiola A, Maira G, Luciani P, Mancini G, Arancia G. A new transfection strategy in the photodynamic therapy of malignant gliomas. Cytometry A (2008) 73A: 66
10. (**)Bombelli C, Faggioli F, Giansanti L, Luciani P, Sacco MG. PEGylated lipoplexes: preparation protocols affecting DNA condensation and cell transfection efficiency. J. Med. Chem. (2007) 50:6274-6278. (**) Authors listed in alphabetical order, but contribution as first author
9. Caracciolo G, Pozzi D, Caminiti R, Mancini G, Luciani P, Amenitsch H. Observation of a Rectangular DNA Superlattices in the Liquid Crystalline Phase of Cationic Lipid/DNA Complexes. J. Am. Chem. Soc. (2007) 129:10092-10093.
8. Luciani P, Bombelli C, Colone M, Giansanti L, Ryhänen SJ, Säily VMJ, Mancini G, Kinnunen PKJ. Influence of the Spacer of Cationic Gemini Amphiphiles on the Hydration of Lipoplexes. Biomacromolecules (2007) 8:1999-2003.
7. Molinari A, Bombelli C, Mannino S, Stringaro A, Toccacieli L, Calcabrini A, Colone M, Mangiola A, Maira G, Luciani P, Mancini G, Arancia G. m-THPC-mediated photodynamic therapy of malignant gliomas: Assessment of a new transfection strategy. Int. J. Cancer (2007), 121:1149-1155.
6. Ryhänen SJ, Säily VMJ, Parry MJ, Luciani P, Mancini G, Alakoskela JMI, Kinnunen PKJ. A Counterion Controlled Transition of a Cationic Gemini from Submicroscopic to Giant Vesicles. J. Am. Chem. Soc.(2006), 128:8659-8663.
5. Säily VMJ, Ryhänen SJ, Lankinen H, Luciani P, Mancini G, Parry MJ, Kinnunen PKJ. Impact of Reductive Cleavage of an Intramolecular Disulfide Bond Containing Cationic Gemini Surfactant in Monolayers and Bilayers. Langmuir (2006), 22:956-962.
4. (**)Bombelli C, Borocci S, Diociaiuti M, Faggioli F, Galantini L, Luciani P, Mancini G, Sacco MG. Role of the spacer of cationic gemini amphiphiles in the condensation of DNA. Langmuir (2005) 21:10271-10274. (**) Authors listed in alphabetical order, but contribution as first author
3. (**)Bombelli C, Faggioli F, Luciani P, Mancini G, Sacco MG. Efficient Transfection of DNA by Liposomes Formulated with Cationic Gemini Amphiphiles. J. Med. Chem.(2005) 48:5378-5382. (**) Authors listed in alphabetical order, but contribution as first author
2. Bombelli C, Caracciolo G, Di Profio P, Diociaiuti M, Luciani P, Mancini G, Mazzuca C, Marra M, Molinari A, Monti D, Toccacieli L, Venanzi M. Inclusion of a Photosensitizer in Liposomes Formed by DMPC/Gemini Surfactant: Correlation between Physicochemical and Biological Features of the Complexes. J. Med. Chem. (2005) 48:4882-4891.
