Our Team

Florian Weber

PhD student

"Development of targeted lipid-based tools for non-invasive molecular diagnostic of hepatic fibrosis"

Gina Valentino

PhD student

"Cellular impact of oral lipid formulations designed for the treatment of chronic liver pathologies"

Lisa Rahnfeld

PhD student

"Development of a phospholipid-based depot technology for sustained drug release"

Cristina Zivko

PhD student

"Lipid-based therapeutics for liver fibrosis and their impact on extracellular vesicles"

Aymar Ganguin

PhD student

"Exploiting the potential of bioinspired therapeutics for the treatment of liver diseases"

Simone Aleandri

Senior scientist

Christoph Zimmermann

PhD student

Associated group member in cooperation with Prof. Olivia Merkel, LMU Munich

Florian Weber

PhD student

Pharmacist (state examination), Martin Luther University Halle, Germany

Liver fibrosis is responsible for a high morbidity because of the development of cirrhosis and hepatocellular carcinoma. Due to the high prevalence and mortality of hepatic fibrosis and the necessity of repetitive evaluation of disease progression, my project is about the development and physicochemical characterization as well as in vitro cell culture testing of targeted liposomes for non-invasive diagnostic molecular imaging for an early diagnosis and to improve management strategies of this chronic fibro-proliferative disease.

Gina valentino

PhD student

Pharmacist, ​Università degli Studi della Calabria, Italy

Chronic liver diseases cover a spectrum of pathologies involved in a progressive destruction of liver functional parts, often leading to the loss of organ function. A valid approach to the management of such chronic disorders might be represented by oral dosage forms that could help to increase patient compliance, significantly improving the course of such illnesses. Lipid-based oral medications have been shown to be suitable candidates. The aim of this project is to develop, characterize, and study the efficacy and the mode of action of novel oral phospholipid-based formulations. Oral lipid formulations designed for the treatment of chronic liver pathologies.

Lisa Rahnfeld

PhD student

Pharmacist (state examination), Friedrich-Schiller-University Jena, Germany

My research is about the development of a novel liposomal depot system for the sustained drug delivery. Using depot system the amount of  injections could be decreased to a minimum and therefore we can improve the compliance of patients and  with this we can contribute to an increased quality of life.

Cristina Zivko

PhD student

MSc ETH Pharm. Sc, ETH Zurich, Switzerland

Liver fibrosis is the wound-healing response to chronic hepatic insults, often leading to the loss of organ function. It is characterized by the excessive deposition of scar tissue, a process driven by activated hepatic stellate cells (HSC). The broader aim of our research is to assess the impact of lipid-based therapeutics on extracellular vesicles isolated from hepatic cell lines, used as an in vitro model for the progression of liver fibrosis.

This project is in collaboration with Dr. Gregor Fuhrmann, at the Helmholtz-Institute for Pharmaceutical Sciences Saarland (HIPS), Germany.

Aymar Ganguin

PhD student

M. Sc. In Molecular Life Sciences with specifications in Biochemistry and chemical Biology, University of Bern, Switzerland

Simone Aleandri

Senior scientist

PhD, Sapienza University of Rome, Italy

Since the beginning of my studies, I have been interested in working at the interface of chemistry and biology. Through the years, I investigated the biophysical characteristics of bio-membrane; their interaction with drugs, proteins, and fluorescent probes. I had the chance to characterize lipid formulations for different purposes and use them as drug carriers systems. My research is now focused predominantly on the development of a lipid based gel delivery systems. These materials exhibit a unique combination of properties: they are biocompatible and able to entrap molecules of various polarities and sizes; they have a soft-gel consistency that enables them to act as depot and thus enhance the epithelium drug permeability achieving exquisite spatial, temporal and dosage control when administered topically or subcutaneously.

https://publons.com/researcher/3189516/simone-aleandri

https://www.researchgate.net/profile/Simone_Aleandri2

Christoph Zimmermann

PhD student

Pharmacist (state examination), Ludwig-Maximilians-University Munich, Germany
B.Sc. Management and Technology, Technical University Munich, Germany

My research studies the microfluidic assembly of siRNA embedded nanoparticles to treat allergic asthma. It is in cooperation with Prof O. Merkel at the department of pharmaceutical technology at the LMU Munich.
My everyday motivation and the foundation for my research is my belief in helping patients by tackling scientific problems. Furthermore, the PhD is a great opportunity to promote a project independently.